RNF8 links nucleosomal and cytoskeletal ubiquitylation of higher order protein structures
نویسندگان
چکیده
RNF8 links nucleosomal and cytoskeletal ubiquitylation of higher order protein structures Comment on: Chahwan R, et al. Cell Cycle 2013; 12:1000–8; PMID:23442799; http://dx.doi.org/10.4161/cc.23947 Richard Chahwan,* Serge Gravel, Takahiro Matsusaka and Stephen P. Jackson*; The Gurdon Institute; University of Cambridge; Cambridge, UK; Department of Zoology; University of Cambridge; Cambridge, UK; Department of Biochemistry; University of Cambridge; Cambridge, UK; Current affiliation: Department of Cell Biology; Albert Einstein College of Medicine; New York, NY USA; Current affiliation: Department of Medical Genetics; University of Sherbrooke; Sherbrooke, QC Canada; *Email: [email protected] and [email protected]; http://dx.doi.org/10.4161/cc.24402
منابع مشابه
ATM targets hnRNPK to control p53
RNF8 links nucleosomal and cytoskeletal ubiquitylation of higher order protein structures Comment on: Chahwan R, et al. Cell Cycle 2013; 12:1000–8; PMID:23442799; http://dx.doi.org/10.4161/cc.23947 Richard Chahwan,* Serge Gravel, Takahiro Matsusaka and Stephen P. Jackson*; The Gurdon Institute; University of Cambridge; Cambridge, UK; Department of Zoology; University of Cambridge; Cambridge, UK...
متن کاملDifferences in regulation and function of E-cyclins in human cancer cells
RNF8 links nucleosomal and cytoskeletal ubiquitylation of higher order protein structures Comment on: Chahwan R, et al. Cell Cycle 2013; 12:1000–8; PMID:23442799; http://dx.doi.org/10.4161/cc.23947 Richard Chahwan,* Serge Gravel, Takahiro Matsusaka and Stephen P. Jackson*; The Gurdon Institute; University of Cambridge; Cambridge, UK; Department of Zoology; University of Cambridge; Cambridge, UK...
متن کاملA new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure.
The ubiquitin ligases RNF8 and RNF168 orchestrate DNA damage signalling through the ubiquitylation of histone H2A and the recruitment of downstream repair factors. Here, we demonstrate that RNF8, but not RNF168 or the canonical H2A ubiquitin ligase RNF2, mediates extensive chromatin decondensation. Our data show that CHD4, the catalytic subunit of the NuRD complex, interacts with RNF8 and is es...
متن کاملRNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly
DNA-damage signaling utilizes a multitude of posttranslational modifiers as molecular switches to regulate cell-cycle checkpoints, DNA repair, cellular senescence, and apoptosis. Here we show that RNF8, a FHA/RING domain-containing protein, plays a critical role in the early DNA-damage response. We have solved the X-ray crystal structure of the FHA domain structure at 1.35 A. We have shown that...
متن کاملRNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins
Accumulation of repair proteins on damaged chromosomes is required to restore genomic integrity. However, the mechanisms of protein retention at the most destructive chromosomal lesions, the DNA double-strand breaks (DSBs), are poorly understood. We show that RNF8, a RING-finger ubiquitin ligase, rapidly assembles at DSBs via interaction of its FHA domain with the phosphorylated adaptor protein...
متن کامل